method for the coating of vascular prosthesis with polymeric materials bioartificiali consisting of mixtures or ipns (polymeric networks interpenetrate) of polymers and biological nature polysaccharidebiodegradable polymers and bioriassorbibili

摘要

a vascular prosthesis coated with a polymeric material bioartificiale is formed from a porous tubular structure of a material in the form of a wire having a rivestim biocompatibiliwater of one or more layers (preferably three) of this material bioartificiale mixed with a plasticizer to make the implant raincoat in the blood without the need for precoagulazione.the substrate may be a porous prosthetic vascular prosthesis of dacron (pet), which may be woven and knotted or whether or not coated with pyrolytic carbon.the polymeric material can be any mixture bioartificiale or hyp of a biological nature saccaridica polymer, preferably ialuronico acid, alginic acid, use.with a synthetic biodegradable polymer and bioriassorbibile, preferably belonging to the class of polymers of lactic acid of the glycolic acid, the caprolattone.of statistical copolymers with polyethylene glycol or blocks of polyvidone.after treatment, coating and drying, can be repeated several times (preferably three)it is measured the porosity is reduced to about 1% of the porosity of the graft before coating.according to the above, is the subject of the invention produce a vascular prosthesis with improved characteristics.a further subject of the invention is the creation of a synthetic vascular prosthesis impervious to blood.a further subject of the invention is the creation of a vascular prosthesis with improved coated with polymers bioartificiali.consisting of mixtures or ipns (polymeric networks interpenetrate) polymer organic nature saccaridica, preferably ialuronico acid, alginic acid, use.with biodegradable synthetic polymers and bioriassorbibili, preferably belonging to the class of polymers of lactic acid and glycolic acid, of the caprolattone.of statistical copolymers with polyethylene glycol or blocks of polyvidone.still an object of the invention is the construction of an innovative method for the preparation of vascular prosthesis coated polymeric materials bioartificiali that make the prosthetic impermeabile in the blood.