BIOSYNTHETIC PRODUCTION OF 6(R)-2-(8(S)-HYDROXY-2(S), 6(R)-DIMETHYL-1,2,6,7,8,8A(R)-HEXAHYDRONAPHTHYL)-ETHYL-4 (R)-HYDROXY-3,4,5,6-TETRAHYDRO-2H-PYRAN-2-ONE TRIOL ACID BY ENZYMATIC HYDROLYSIS OF LOVASTATIN ACID USING AN ENZYME DERIVED FROM__LONOSTACHYS COMPACTIUSCULA

摘要

Biosynthetic production of6(R)-[2-(8(S)-hydroxy-2(S),6(R)-dimethyl-1,2,6,7,8,8a-(R)-hexahydronaphthyl)ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one triol acid is obtained byenzymatic hydrolysis of lovastatin acid or a saltthereof, by treating it with Clonostachyscompactiuscula or mutants thereof, or a hydrolasederived therefrom. The triol acid may be convertedin a straightforward manner to its lactone form; andboth are inhibitors of HMG-CoA reductase and thususeful as antihypercholesterolemic agents, and mayalso serve as intermediates for preparation of otherHMG-CoA reductase inhibitors.