Enhancement of ribozyme catalytic activity by adjacent promoter oligonucleotides (ENHANCEMENT OF RIBOZYME CATALYTIC ACTIVITY BY A NEIGHBORING FACILITATOR OLIGONUCLEOTIDE)

摘要

Disclosed herein are methods of increasing ribozyme catalytic activity without reducing specificity, comprising contacting the RNA molecule with a ribozyme and a promoter oligonucleotide. The present invention also provides a composition comprising a ribozyme and an effective amount of a promoter oligonucleotide. The ribozyme also catalyzes the cleavage of the target RTI ID = 0.0 RNA & ²⁺And Mn²⁺Methods for decreasing the concentration of RTI ID = 0.0