CDNA sequence of dengue virus serotype 1 (Singapore strain) of dengue virus serotype 1 (Singapore strain)

摘要

DEN1-S275 / 90 of the present invention (ECACC V92042111) relates to a novel strain of Dengue virus serotype 1. The complete cDNA sequence of the virus has been cloned and its protein-encoding fragment has been used in constructing the expression plasmid. Inactivated forms of DEN1-S275 / 90, DEN1-S275 / 90 polypeptides or fusion proteins thereof can be incorporated into vaccines for immunization against DEN1-S275 / 90 and other DEN1 viruses. The invention further provides diagnostic reagents, ie labeled antibodies to the DEN1-S275 / 90 protein, and kits for detecting the DEN1 virus.