1-PYRIDO(3,4-B)-1,4-OXAZINYL-4-YL-1H-INDOLES, METHOD OF THEIR SYNTHESIS, COMPOSITION ON THEIR BASIS AND DERIVATIVE OF N-(4-PYRIDINYL)-1H-INDOLE-1-AMINE

摘要

FIELD: chemistry of heterocyclic compounds. SUBSTANCE: product: 1-[pyrido-[3,4-b] -1,4-oxazinyl-4-yl] -1H-indoles of the formula (I) (image), where R₁ H, R₂ H or lower alkyl, R H, OH, benzyloxy or group of the formula (II) (image), where R₄ H; R₅ - lower alkyl. Composition showing capability to restore memory disorder and/or antidepressant activity contains compound (I) in the form effective oral, parenteral or internal dose from 1 to 100 mg/kg body weight/day. Compounds (I) were synthesized by cyclization of compound (III) (image) in the presence of strong base. Synthesized compounds were used in medicine. EFFECT: improved method of synthesis. 10 cl