SHINKISEFUAROSUHORINJUDOTAIOYOBISONOSEIZOHO

摘要

NEW MATERIAL:A compound shown by formula I {R is (substituted) lower alkyl, lower alkenyl (with the proviso that 1-carboxy-1-vinyl is omitted), etc.; Q is group shown by formula II-IV [R1 is H or acetyl; R2 is H, carboxyl or carboxymethyl; Y is S or O; Z is S, O or (lower alkyl-substituted) imino]}. EXAMPLE:7beta-[2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[5-( 3,4- dihydroxyphenyl)-1,3,4-oxadiazol-2-yl]thiomethyl-3-cephem-4-carboxylate sodium salt (syn isomer). USE:An antibacterial agent against gram-negative bacteria. PREPARATION:A compound shown by formula V [R3 is amino-protecting group; R4 is (substituted) lower alkyl, etc.; R5 is H or carboxyl protecting group; X is eliminable group] is treated with a compound shown by the formula HS-Q1 (Q1 is Q, etc.) to give a compound shown by formula VI, which is optionally deprotected.