TRANSGENIC MOUSE CONTAINING INTRODUCED VARIATION GENE OF HUMAN RETINOIC ACID RECEPTOR AND SCREENING OF AGONIST OR ANTAGONIST AGAINST HUMAN RETINOIC ACID RECEPTOR USING THE TRANSGENIC MOUSE

摘要

PURPOSE: To obtain a transgenic mouse useful for the screening of an agonist, etc., against human retinoic acid receptor by introducing a gene coding a dominant-negative variation receptor of human retinoic acid receptor under specific introducing condition. ;CONSTITUTION: A gene coding α dominant-negative variation receptor having a structure obtained by converting the 303rd Gly of human retinoic acid receptor a to Gln is introduced under the domination of a keratin-14 promoter. A transgenic mouse expressing a variation receptor fin epidermally specific state is obtained by this process.;COPYRIGHT: (C)1995,JPO