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SUBSTITUTED BENZENESULFONYL UREAS AND BENZENESULFONYLTHIOUREAS, PROCESS OF THEIR PREPARATION AND USE OF PHARMACEUTICAL PREPARATIONS BASED ON SAID COMPOUNDS, AS WELL AS MEDICAMENTS CONTAINING THEREOF
SUBSTITUTED BENZENESULFONYL UREAS AND BENZENESULFONYLTHIOUREAS, PROCESS OF THEIR PREPARATION AND USE OF PHARMACEUTICAL PREPARATIONS BASED ON SAID COMPOUNDS, AS WELL AS MEDICAMENTS CONTAINING THEREOF
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机译:取代的苯磺酰脲类和苯磺酰脲类,其基于所述化合物以及包含所述药物的药物制剂的制备和使用过程
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Substd. benzene sulphonyl urea and thiourea cpds. of formula (I) and their salts are new. R1 = H, 1-7C alkyl or 3-7C cycloalkyl; R2 = H, 1-6C alkyl, 1-6C alkoxy, 1-6C mercaptoalkyl, 3-6C cycloalkyl, or 1-8C chain (in which 1-4C atoms are replaced by Het), F or Cl; R3, R4 = H, 1-12C alkyl, 3-10C cycloalkyl, 1-6C fluoroalkyl, 3-6C fluorocycloalkyl, or 1-10C chain in which 1-4C atoms are replaced by Het; or R3+R4 = (CH2)p, opt. with 1 or more CH2 replaced by heteroatoms; p = 2-8; Q, X = O or S; Y = (CR5R6)m; R5; R6 = H, Me or Et (opt. different in different CR5R6 gps.); Het = heteroatom such as O, N or S, m = 1-4.
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