DNA SEQUENCES ENCODING AMINO ACID SEQUENCE OF HUMAN ERYTHROPOIETIN, VECTORS CONTAINING SUCH SEQUENCES, PROKARYOTIC AND EUKARYOTIC HOST CELLS TRANSFORMED BY SUCH VECTOR, PROCESS FOR PREPARING HUMAN ERYTHROPOIETIN, RECOMBINANT HUMAN ERYTHROPOIETIN AND PHARMACEUTICAL PREPARATION IN WHICH ERYTHROPOIETIN IS COMPRISED

摘要

The invention refers to recombinant DNA plasmid vector containing cDNA encoding human EPO of clone lambda HEPOFL13 (ATCC 40153) and mammalian cell transformed with this vector or with a plasmid which contains the entire bovine papilloma virus DNA and the cDNA sequence of Table 3 coding for human EPO are which useful in the preparation of recombinant human erythropoietin which is characterized by the presence of O-linked glycosilation.