GENE THERAPY OF TUMORS WITH AN ENDOTHELIAL CELL-SPECIFIC, CELL CYCLE-DEPENDENT ACTIVE COMPOUND

摘要

The invention concerns a DNA sequence for the genetic therapy of tumours. The essential components of the DNA sequence consist of an activator sequence, a promoter module and a gene for the active substance. The activator sequence is activated cell-specifically in proliferating endothelium cells or cells neighbouring these endothelium cells. The promoter module regulates this activation specifically according to the cell cycle. The active substance is an angiogenesis inhibitor or a cytostatic or cytotoxic molecule. The DNA sequence is introduced into a viral or non-viral vector, supplemented by a ligand having affinity for the activated endothelium cell.