HISTIOCYTE-SECRETED FACTOR (HSF), A NOVEL CYTOKINEHISTIOCYTE-SECRETED FACTOR (HSF), A NOVEL CYTOKINE

摘要

The present invention provides isolated nucleotide sequences encoding histiocyte-secreted factor (HSF) or an HSF analog and the complements of these sequences. Also provided are isolated nucleotide sequences comprising a portion of an HSF genomic sequence, which can consist of coding regions, non-coding regions, or both. The invention includes nucleotide sequences suitable for use as hybridization probes and amplification primers and for insertion into vectors for propagation and expression. The invention also provides isolated HSF polypeptides and analogs, along with anti-HSF antibodies. These polypeptides and antibodies are useful in cancer chemotherapy and as tools in the study of tumor regression.