HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS,HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS, HPPAR GAMMA AND HPPAR GAMMA 2 HPPAR GAMMA AND HPPAR GAMMA 2

摘要

The present invention relates to two novel peroxisome proliferator activated receptor subtypes, hPPARη and hPPARη2. hPPARη and hPPARη2 differ from mouse peroxisome proliferator activated receptor η in nucleotide sequence and amino acid sequence. The invention provides isolated, purified, or enriched nucleic acid encoding hPPARη or hPPARη2 polypeptides and vectors containing thereof, cells transformed with such vectors, and method of screening for compounds capable of binding hPPARη or hPPARη2 polypeptides. The invention also provides isolated, purified, enriched, or recombinant hPPARη or hPPARη2 polypeptides, antibodies having specific binding affinity to hPPARη or hPPARη2 polypeptides, and hybridomas producing such antibodies.