TREATMENT OF TUMORS WITH CELLS EXPRESSING INTERFERONS, TUMOR NECROSIS FACTORS, OR OTHER CYTOKINES

摘要

A method of treating a tumor in a host which comprises administering to the site of the tumor non-tumor cells which express one or more agents selected from the group consisting of an interferon, a tumor necrosis factor, and GM-CSF. When the agent is an interferon or a tumor necrosis factor such method provides for a local, non-immune mediated anti-tumor response. The cell which expresses the interferon or tumor necrosis factor and which is administered to the site of the tumor also may be administered, in one embodiment, in conjunction with (a) a non-tumor cell that is engineered with a polynucleotide encoding a cytokine; and (b) tumor cells of the type of tumor which is being treated, in order to provide an immediate, non-immune mediated anti-tumor response, followed by an immune response against the tumor.