Piperidine derivatives as 5-HT4 receptor antagonists (Piperidine Derivatives as 5-HT4 Receptor Antagonists)

摘要

The present invention also relates to the compounds of the general formula (I) and pharmaceutically acceptable salts thereof and the compounds of the general formula (I) or the pharmaceutically acceptable salts or the salts thereof wherein the CO-Y bond is substituted by a heterocyclic bioequivalent I) and for use as pharmaceutical preparations in the treatment of gastrointestinal tract disorders, cardiovascular disorders and CNS disorders.;X-CO-Y-Z (1);Wherein X is a monocyclic or polycyclic aromatic group and Y is O or NH; Z is the following formula;(Wherein,-(CH₂)_n^OneIs asked for carbon; n^OneIs 0, 1, 2, 3 or 4; p is 0, 1, 2 or 3; R^aR₇Substituted straight chain or branched chain alkylene having 1 to 6 carbon atoms, wherein R₇Is a 9-or 10-membered fused bicyclic heteroaryl linked via a 3-to 8-membered cycloalkyl, a 3-to 8-membered heterocyclyl, a 5-or 6-membered monocyclic heptaloaryl or a carbon, or R₇C_2-7Alkoxycarbonyl or a secondary or tertiary hydroxy substituted C_1-6Alkyl; R₆Is hydrogen or C_1-6Alkyl.