NOVEL TRICYCLIC DERIVATIVES, THEIR PREPARATION, THEIR APPLICATION TO THE PREPARATION OF OPTICALLY ACTIVE OR RACEMIC COLCHICINE AND THIOCOLCHICINE AND ANALOGS OR DERIVATIVES AND INTERMEDIATES

摘要

The invention relates to the compounds (I): embedded image in which R1 and R2 = alkyl and R3 = hydrogen or ASO2, A being in particular alkyl or optionally substituted phenyl, BR/ or R2 and R3 = hydrogen or alkyl and R1 = ASO2, or R1, R2 and R3 = hydrogen or alkyl, R1 = ASO2 or hydrogen and R2 and R3 form a protecting group, or R 3 = ASO 2 and R 1 and R 2 form a protective group, their preparation, their application to the preparation of racemic and optically active colchicine and thiocolchicine and of intermediate analogs or derivatives. as well as intermediaries.