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Mammalian model system and methods of testing immuno-or drug prophylaxis of fetal infection by HIV-1 or other lentiviruses
Mammalian model system and methods of testing immuno-or drug prophylaxis of fetal infection by HIV-1 or other lentiviruses
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机译:测试HIV-1或其他慢病毒对胎儿的免疫或药物预防作用的哺乳动物模型系统和方法
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摘要
A mammalian model system for the pathogenesis of lentiviral, especially HIV-1, infection during fetal gestation is disclosed. The model system is used in methods of testing various regimens for prophylaxis of fetal lentiviral infection. In the model system, fetal infection is established in a pregnant mammal (e.g., a rhesus monkey, Macaca mulatta or a pigtailed macaque, Macaca nemestrina) by ultrasound guided inoculation of an inoculum of a lentivirus, e.g., SIV, into the amniotic fluid. The testing methods include the analysis of the effectiveness of potential immunotherapeutic and transplacental drug therapy regimens. The model will also allow testing which viral isolates are pathogenic to the developing fetus.
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