Compound composition useful for increasing the endogenous production or release of hormonio growth in human being or animal and for the treatment of osteoporosis processes to increase the levels ofGrowth hormone in a human or an animal and the effectiveness of feed to promote growth to increase the production of milk and improve the quality of the carcase cattle to treat or preventA condition selected for treating osteoporosis and to prepare a composite

摘要

The present invention is directed to certain piperidine, pyrrolidine, and hexahydro-1H-azepine compounds of general structural formula (I) wherein R1, R3, R4, R5, A, W, X, Y, and n are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.