Regal-selective process to synthesize any cis-1-amino-2-indanol enanciomer or mixture of said enanciomers in which (1s.2r) or (1r-2s) - indene oxide is substantially converted to 1s-amino-2r- indanol or 1r-amino-2s-indanol and to synthesize 1s-amino-2r-indanol or 1r-amino-2s-indanol

摘要

A regioselective process is disclosed for synthesis of 1R-amino-2S-indanol or 1S-amino-2R-indanol, wherein the stereochemical integrity of the carbon-oxygen bond at C-2 in the indene oxide starting material is retained.