DNA encoding human protein S including a polypeptide with human protein S activity, DNA vectors, host cells including cell cultures transformed with these vectors, method for producing human protein S, human protein S prepared by the method, and pharmaceutical agent consisting of human protein S

摘要

The present invention comprises novel DNA compounds which encode human protein S activity. The human protein S cDNA sequence consists of a coding region for a 676 amino acid precursor; the coding region encodes a 41 amino acid leader peptide, 635 amino acids corresponding to the mature protein, and a stop codon. Eukaryotic expression vectors have been constructed which comprise the novel protein S activity-encoding DNA and drive expression of protein S when transformed into an appropriate host cell.