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Racemization procedure for use in the preparation of levobupivacaine and related piperidine carboxanilide aesthetics
Racemization procedure for use in the preparation of levobupivacaine and related piperidine carboxanilide aesthetics
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机译:用于制备左旋布比卡因和相关哌啶羧酰苯胺的外消旋方法
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摘要
An optically-enriched piperidine-2-carboxanilide compound, in which the piperidine is optionally N-alkylated, is racemised by heating the compound in an aqueous medium, provided that the medium includes an organic cosolvent if the compound is N-alkylated. This process is particularly valuable, in conjuction with a resolution process, for the manufacture of levobupivacaine.
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