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use of lattoferrina for the topical therapy of acute or recurrent infections caused by streptococcus pyogenes or other

机译:lattoferrina用于由化脓性链球菌或其他引起的急性或复发性感染的局部治疗

摘要

some pathogenic bacteria are able to penetrate within human cells remain viable in the fagosoma or replicate in the cytoplasm leaking from the vacuole.lisando the cell and spreading the infection.in this patent is demonstrated for the first time, regardless of its antibacterial activity.a antiinvasiva activity towards gram + organisms intracellular pathogens possessed by the lattoferrina, glycoprotein present in secretions and leukocytes in granules of neutrophils.to a lesser extent, also polipeptidici fragments of protein and other transferrine, altered chemically, for example, the ovotransferrina glycosylated.show the same activity antiinvasiva.it was we noted that the lattoferrina has a protection activities of human epithelial cells in culture from invasion of streptococcus pyogenes and staphylococcus aureus.pathogenic microorganisms, gram +, which proved to be the ability to invade human cells.the lattoferrina, preventing these microorganisms to "hide" within the cells.it makes them aggredibili by drug therapy and cell factors and mood are the body's defences.the activities of the lattoferrina antiinvasiva.it can be generalized and usable for the topical therapy of many acute or recurrent bacterial infections of skin and mucous membranes by which oropharyngeal, nasal, intestinalbronchial, vaginal and other. finally, it is known as the lattoferrina is absolutely harmless for topical use and can be produced industrially in large quantities.
机译:一些致病细菌能够穿透人类细胞,使其在前庭腺瘤中保持活力或在从液泡中渗出的细胞质中复制.lisando细胞并传播感染。无论是否具有抗菌活性,该专利都首次得到证明。对革兰氏菌属所具有的革兰氏阳性生物的抗入侵活性,嗜中性粒细胞颗粒中分泌物中存在的糖蛋白和白细胞中存在的糖蛋白的糖蛋白,蛋白质和其他运铁蛋白的脂肽片段也发生了化学变化,例如被糖基化的卵转铁蛋白。我们注意到,lattoferrina对培养的人上皮细胞具有保护作用,可防止化脓性链球菌和金黄色葡萄球菌的侵袭。病原微生物gram +证明是入侵人细胞的能力。防止这些微生物“隐藏”在细胞内。它们通过药物疗法聚集,细胞因子和情绪是人体的防御力。lattoferrina抗侵袭血管的活性。它可以被普遍化,并可用于皮肤和粘膜的许多急性或复发性细菌感染的局部治疗,通过这种感染,口咽,鼻,鼻,肠支气管,阴道等。最后,它被称为lattoferrina,对于局部使用绝对无害,可以工业化大量生产。

著录项

  • 公开/公告号ITRM950473A1

    专利类型

  • 公开/公告日1997-01-13

    原文格式PDF

  • 申请/专利权人 VALENTI PIERA;ANTONINI GIOVANNI;

    申请/专利号IT1995RM00473

  • 发明设计人 ANTONINI GIOVANNI;VALENTI PIERA;

    申请日1995-07-12

  • 分类号A61K38/40;

  • 国家 IT

  • 入库时间 2022-08-22 03:24:40

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