NEUROTROFINA-3, A NEW NEUROTROPHIC FACTOR RELATED TO THE NERVOUS GROWTH FACTOR AND NEUROTROPHIC FACTOR DERIVED FROM THE BRAIN.

摘要

THE PRESENT INVENTION REFERS TO NEUROTROPHINE-3 (NT-3), A RECENTLY DISCOVERED MEMBER OF THE BDNF GENES FAMILY. IT IS BASED, IN PART, ON THE REGION IDENTIFICATION OF THE NUCLEIC ACID SEQUENCE HOMOLOGALLY SHARED BY BDNF AND NGF (US PATENT SERIAL NUMBER 400,591, REGISTERED AUGUST 30, 1989, INCORPORATED BY REFERENCE HEREIN). PURSUANT TO THE PRESENT INVENTION, THESE REGIONS OF HOMOLOGY MAY BE USED TO IDENTIFY NEW MEMBERS OF THE BDNF / NGF GEN FAMILY; SUCH METHODOLOGY WAS USED TO IDENTIFY THE NT-3. THE PRESENT INVENTION PROVIDES THE GENES AND GENE PRODUCTS OF THE NEW BDNF / NGF RELATED TO THE NEOTROPHIC FACTORS IDENTIFIED BY THESE METHODS. PURSUANT TO THE INVENTION, NT-3 MAY BE USED IN THE DIAGNOSIS AND / OR TREATMENT OF NEUROLOGICAL DISEASES, INCLUDING ALZHEIMER'S EVIL AND PARKINSON'S DISEASES. BECAUSE IT HAS BEEN OBSERVED THAT THE NT-3 EXHIBITS A SPECTRUM OF ACTIVITY DIFFERENT FROM THE SPECIFICATIONS OF BDNF OR NGF, THE NT-3 PROVIDES NEW AND VALUABLE OPTIONS TO INDUCE REGENERATION AND REPAIR IN THE CENTRAL NERVOUS SYSTEM.