An isolated nucleic acid molecule encoding C. albicans profilin. Preferably, the C. albicans profilin has the amino acid sequence of SEQ. ID. NO.: 2 and the nucleotide sequence of SEQ. ID. NO.: 1. The invention also concerns a nucleic acid molecule having a sequence complementary to the above sequences of 5' and 3' flanking regions thereof. The invention further concerns nucleic acid vectors comprising a DNA sequence coding for C. albicans profilin, host cells containing such vectors, and polypeptides comprising C. albicans profilin. Preferably, the polypeptide is full-length C. albicans profilin or recombinantly produced C. albicans profilin. The present invention also concerns methods for detecting nucleic acids coding for C. albicans profilin and for detecting anti-fungal agents that target C. albicans profilin.
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