Method of detection of polymorphism and a loss of heterozygosity in a lung tumor suppressor gene

摘要

The invention concerns a method of detection of polymorphism and/or loss of heterozygosity in the lung tumor suppressor gene located in chromosomal region 5p15-q21, its locus being characterized by GeneBank sequence M99171, said method being characterized by mapping human cell specimens using as probes the oligonucleotides 5'GATTTGAGGGTCATATTCA3' (SEQ ID NO:1) and/or 5'CAGTAAATGGTGCTTGGA3' (SEQ ID NO:2). Said method is useful in the diagnosis of non-small cell lung cancer (NSCLC).