COMPLEXONES WITH THE STRUCTURE OF N-2-(AZOL-1(2)-YL)ETHYLIMINODIACETIC ACIDS, SYNTHESIS, ANALYTICAL STUDY AND BIOLOGICAL APPLICATIONS

摘要

Complexones having the structure of N-2-(azol-1(2)-yl(ethyl-iminodiacetic acids, synthesis, analytical study and biological applications, characterized by their complexing capacity over Ca²⁺, Mg²⁺ ions and other bivalent cations, lanthanides and transition metals. In the formula azolN-CH₂-CH₂-N(CH₂-CO₂R)₂ (I), azol is pirazol; 3,5-dimethylpirazol; indazol; etc. and R is alkyl or H or Na. The compounds having the general formula (I), are obtained by an alkylation reaction of methyl iminodiacetate with N-bromoethylazols and further hydrolysis in acid or basic medium. The process may be modified by alternative synthetic processes which involve N-aminoethylazols as starting materials or the use of cyclization processes in the preparation of N-substituted azol. They can be applied in spectroscopy and nuclear magnetic resonance (NMR) imaging of hydrogen or other nuclei as extrinsic probes of Ca²⁺, Mg²⁺ or other metal ions and as contrast agents, in solutions, biological extracts, tissues, entire animals and human beings.