TETRAZOLE DERIVATIVES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION SHOWING PROPERTY OF ANTAGONIST OF ANGIOTENSIN-II RECEPTORS

摘要

FIELD: organic chemistry. SUBSTANCE: product: 5-[4'-[2-butyl-4-chloro-5-(3-methyl-1,2,4-oxaziazole-5-yl) -1-imidazolylmethylbiphenyl-2-yl] ]-triphenylmethyl-1H-tetrazole, empirical formula is C₄₃H₃₇N₈ClO, yield is 43%, m. p. is 175-177 C. Analysis: thin-layer chromatography in solvent toluene:ethyl acetate, 10:1; value R_f = 0.4. Synthesized compounds were used in medicine for hypertension and cardiac-vascular diseases treatment. EFFECT: improved method of synthesis. 7 cl, 3 dwg