THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND THEIR DERIVATIVES WHICH INFLUENCE ENDOTHELIN ACTIVITY

摘要

Biphenylsufonamides of the following formula and methods for modulating or altering the activity of the endothelin family of peptides are provided. The sulfonamides may be used for inhibiting the binding of an endothelin peptide to an endothelin receptor by contacting the receptor with the sulfonamide CHEM or a pharmaceutically acceptable salt, acid or ester thereof, wherein Ar2 is CHEM and wherein Ar1, R13 and R26 are as defined herein.m