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GRANULATION PRODUCT AS AN ORAL DOSING FORM OF BETA-LACTAM ANTIBIOTICS, PROCESS FOR PREPARING THEREOF, AS WELL AS THE ORAL DOSING FORM AND PROCESS OF ITS PREPARATION
GRANULATION PRODUCT AS AN ORAL DOSING FORM OF BETA-LACTAM ANTIBIOTICS, PROCESS FOR PREPARING THEREOF, AS WELL AS THE ORAL DOSING FORM AND PROCESS OF ITS PREPARATION
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机译:制备成β-内酰胺类抗生素口服制剂的制剂及其制备方法,口服制剂及其制备方法
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摘要
In the present invention, there is disclosed a process for the preparation of a granulate, comprising a water soluble, orally active beta-lactam antibiotic, wherein water solubility ratio ranges within 1 to less than or equal to 10 and including the steps of: a. moistening components making up the granulate with an aqueous solution containing 0 to 0.5 percent by weight, preferably 0 to 0.1 percent by weight of a wet granulation binding agent, the percentage based on the granulate total weight; b. screening the wet mass through a 2 mm sieve; c. drying the product obtained in step b.; d. screening the dry product of step c. through an at least 0.71 mm sieve. The obtained granulate is suitable for the preparation of quickly disintegrating oral pharmaceutical composition.
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