Antitüberküloz aktif dogal bilesiklerin eldesi ve yapi tayinleri.

摘要

According to invention, 7 diterpene consisting of 6 abietic and 1 primary structures have been extracted from the acetone extract of the roots of an sage tea species, Salvia Multicaulis, their formations have been determined by spectroscopic methods (TR, UV, IH and 13C NMR and MS) and referred as multicaulis (1), 12-dimethyl multicaulis (2), multiorthoquinone (3), 12-dimethylmultiorthoquinone (4), 12-methyl-5-dehydrohorminone (5), 12-methyl-5-dehydro-acetylhorminone (6) and salvipimarone (7). They have been thought to be active in formation and detected to have higher activity as a result of anti-tuberculosis test against Mycobacterium tuberculosis by liquid micro dilution method and three of these compounds (2, 4 and 6) have been found to be more active than the medication used in tuberculosis treatment like streptomycin, kanamycin, p-aminosalicylic acid (PAS) and isonicotinic acid hydracids (INH).