AQUEOUS LOCAL ANESTHETIC SOLUTION, METHOD FOR IMPROVING SOLUBILITY OF LOCAL ANESTHETIC, LOCAL ANESTHETIC AGENT WITH DECREASED NEUROTOXICITY AND METHOD FOR DECREASING NEUROTOXICITYOF LOCAL ANESTHETIC AGENT

摘要

An aqueous local anesthetic solution having a pH of 6.5-8.5, whichcontains a local anesthetic included in cyclodextrin or a derivativesthereof in a concentration of the local anesthetic of not less than0.02%, a method for improving solubility of local anesthetic in waterat a pH of 6.5-8.5, comprising including the local anesthetic incyclodextrin or a derivative thereof, a local anesthetic agentcomprising an inclusion compound of local anesthetic in cyclodextrin ora derivative thereof, a method for decreasing neurotoxicity of localanesthetic agent, comprising including the local anesthetic incyclodextrin or a derivative thereof, and an inclusion compound oflocal anesthetic in cyclodextrin or a derivative thereof. The localanesthetic agent and aqueous local anesthetic solution of the presentinvention have decreased neurotoxicity, so that the duration ofanesthesia can be controlled clinically safely by reducing/increasingits concentration or dose. In particular, the aqueous local anestheticsolution can be used at a pH near that of a living body. Thus, it canbe used even when living tissue has an acidic pH. Moreover, the paincaused by local acidosis at an injection site by a conventional localanesthetic dissolved in an acidic solution can be reduced.