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METHOD FOR SEQUENCING NUCLEIC ACIDS USING MATRIX-ASSISTED LASER DESORPTION IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY
METHOD FOR SEQUENCING NUCLEIC ACIDS USING MATRIX-ASSISTED LASER DESORPTION IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY
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机译:基质辅助激光解吸电离飞行时间质谱法分离核酸的方法
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摘要
The invention provides an analytical method for determining the nucleotide sequence of nucleic acid analytes, including chemically modified oligonucleotides. This new method utilizes matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) with delayed pulsed ion extraction.
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