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PURIFIED TSH PREPARATION, PROCESS FOR ITS PRODUCTION AND ITS USE FOR THE PRODUCTION OF TSH TRACERS FOR TSH RECEPTOR ASSAYS AND IN TSH RECEPTOR ASSAYS
PURIFIED TSH PREPARATION, PROCESS FOR ITS PRODUCTION AND ITS USE FOR THE PRODUCTION OF TSH TRACERS FOR TSH RECEPTOR ASSAYS AND IN TSH RECEPTOR ASSAYS
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机译:纯净的TSH制备,生产过程及其在TSH受体检测和TSH受体检测中生产TSH示踪剂的用途
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摘要
TSH preparation which is obtained by purification of crude bovine TSH (thyrotropin), can be converted by direct radioiodination into a radioiodinated TSH tracer for a TSH receptor assay, has a biological activity of more than 40 IU TSH/mg protein and is obtainable by purification of commercial crude bovine TSH by affinity chromatography over an anti-TSH antibody column and subsequent ion exchange chromatography over a weakly acidic cation exchanger having terminal carboxyl groups and based on a polyamide-coated silica gel, a corresponding process for its production and its use for the production of a TSH tracer, in particular for a TSH receptor autoantibody assay.
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机译:通过纯化粗牛TSH(促甲状腺激素)获得的TSH制剂,可通过直接放射性碘化转化为放射性碘化的TSH示踪剂用于TSH受体测定,其生物学活性超过40 IU TSH / mg蛋白,可通过纯化获得通过在抗TSH抗体柱上进行的亲和层析,以及随后在具有末端羧基的弱酸性阳离子交换剂上进行的离子交换层析,并基于聚酰胺包被的硅胶,制备商品化的牛TSH,相应的生产方法及其用途TSH示踪剂的生产,特别是用于TSH受体自身抗体测定的试剂。
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