DERIVATIVES OF AMINO-7-(CHR₂R₃)-3H,5H-PYRROLO-3,2-D-PYRIMIDINE-4-ONE, METHODS OF THEIR SYNTHESIS AND A METHOD OF SELECTIVE INHIBITION OF MAMMALIAN T-LYMPHOCYTES PROLIFERATION AND NO EFFECTING ON CHR₂R₃-LYMPHOCYTES

摘要

FIELD: organic chemistry. SUBSTANCE: invention proposes derivatives of 2-amino-7-(CHR₂R₃)-3H, 5H-pyrrolo-[3,2-d] -pyrimidine-4-one of the formula: where: R₁ - H, NH₂; R₂ - saturated 5-membered heterocycle containing S or O as heteroatom, or 6-membered N-containing heterocycle that can be substituted; R₃ - H, CH₂, CH₂CO₂H, CH₂CONH₂, CO₂CH₃, CO₂H or CH₂CH₂OH,, or R₂ and R₃ together with CH form cyclohexyl- or cyclohexenyl-group. The synthesized compounds are inhibitors of purine-nucleoside phosphorylase. Invention proposes methods of their synthesis and a method of selective inhibition of mammalian T-lymphocytes proliferation but no effecting on B-lymphocytes. EFFECT: improved method of synthesis. 10 cl, 1 tbl