CEPHALOSPORIN COMPOUNDS, THEIR PHARMACEUTICALLY ACCEPTABLE NONTOXIC SALTS, PHYSIOLOGICALLY HYDROLYZABLE ESTERS, ISOMERS HAVING E-CONFIGURATION OF DOUBLE BOND IN PROPENYL GROUP, SYN-ISOMERS AND OPTICAL ISOMERS AND A METHOD OF THEIR SYNTHESIS

摘要

FIELD: organic chemistry, antibiotics. SUBSTANCE: product: cephalosporin of the general formula (I): , its pharmaceutically acceptable nontoxic salt, physiologically hydrolyzable ester, hydrate or solvate or its isomers where Q means CH or N; R¹ means hydrogen or amino-protective group; R² and R³ can be similar or different and mean independently hydrogen or hydroxy-protective group; or R² and R³ together can form cyclic diol-protective group; R⁴ means hydrogen or carboxyl-protective group; R⁵,R⁶ and R⁷ independently mean hydrogen, amino or substituted amino, hydroxy, alkoxy, C_1-4-alkyl, carboxyl or alkoxycarbonyl, or R⁵ and R⁶ together with carbon atoms to which they bound can form C₃-C₇-cycle. EFFECT: improved method of synthesis. 4 cl, 2 tbl