METHOD OF PREPARING THE COMPLEX OF SILIBININE WITH CYCLODEXTRIN, INCLUSION COMPLEX OF SILIBININE WITH CYCLODEXTRIN, PHARMACEUTICAL COMPOSITION SHOWING ANTIHEPATOTOXIC ACTIVITY AND A METHOD OF ITS PREPARING

摘要

FIELD: chemical-pharmaceutical industry. SUBSTANCE: invention relates to new complexes including silibinine with cyclodextrin and presented by groups consisting of α-,β-,γ--cyclodextrin and their corresponding derivative, and a method of their preparing. New complexes containing silibinine show enhanced biological activity as compared with silibinine and can be used in medicine for treatment of different hepatotoxic states. EFFECT: improved method of preparing, enhanced effectiveness. 5 cl