PHOSPHONOCARBOXYLATE COMPOUNDS FOR TREATMENT OF PATIENTS WITH ABNORMAL CALCIUM AND PHOSPHORUS METABOLISM, PHARMACEUTICAL COMPOSITION

摘要

FIELD: organophosphorus compounds. SUBSTANCE: pharmaceutical compositions have pharmaceutically acceptable carriers and phosphonocarboxylate or its pharmaceutically acceptable salt of the formula (I): where A is taken from group involving hydrogen, halogen, SR¹,R²SR¹, amino-, hydroxy-group, free or substituted C₁-C₈-alkyl; B means NH₂ and so on, or A and B are bound covalently with C^* to form monocyclic or bicyclic ring eliciting -structure: . Proposed compositions show strong antiresorptive osseous activity and benefit for treatment of patients with osteoporosis and arthritis. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 11 cl, 74 ex