Bax promoter sequence and screening assays for indentifying agents that regulate bax gene expression

摘要

The present invention provides a substantially purified bax promoter and a nucleic acid molecule containing a nucleotide sequence encoding a gene product operably linked to a bax promoter. The invention also provides a substantially purified active fragment of a bax promoter and a nucleic acid molecule containing a nucleotide sequence encoding a gene product operably linked to an active fragment of a bax promoter. Cell- based screening assays for identifying an effective agent such as a drug that regulates the level of expression of a gene operably linked to a bax promoter, or an active fragment thereof, also are provided.