Vitamin D like from the African clawed frog manner of receptor XOR6, polypeptide, nucleotide array

摘要

(57) Abstract As for this invention which is disclosed, the typical member is called XOR6, it is the new member of the steroid receptor super family of the receptor. This receptor, hydroxy, it is responsiveness in the merukaputo or amino benzoate, it reveals with the embryo of the African clawed frog (Xenopus laevis). Most it has been related XOR6, to the vitamin D3 receptor most closely. As for amino acid array, approximately 73% is identical with DNA join domain, with ligand join domain approximately 42% is identical. Same as the vitamin D3 receptor, XOR6 has the extended D field between DNA and ligand join domain. It has an influence on the capacity where the field to XOR6 DNA join domain, quite acidity is high from amino end, activates the gene. By southern blotting, as for XOR6-related array, existing in the other Vertebrata which includes the person is shown. In addition, the code is done also the probe which is induced from the nucleotide array and creation which body and the cell, and the XOR6 array which contain this has been disclosed the XOR6 receptor. Hydroxy, merukaputo and the amino benzoate qualification the transcription of the receptor of this invention.