Composition to stabilize the enzyme activity and immunoreactivity of creatine kinase and creatine kinase isoenzyme

摘要

PURPOSE: To obtain the subject composition comprising animal serum, creatine kinase (isoenzyme), a buffer solution, a nonreducing polyol and an antioxidant, capable of stabilizing enzymatic activity and immunoreactivity of an enzyme for diagnosing myocardial infarction, etc. ;CONSTITUTION: This composition comprises (A) animal serum, (B) creatine kinase and/or creatine kinase isoenzyme, (C) an effective amount of a buffer solution to maintain pH of the composition at 6.7±0.1, (D) an effective amount of a non-thiol antioxidant to prevent the oxidation of creatine kinase or creatine kinase isoenzyme, (E) an effective amount of a nonreducing polyol to stabilize immunoreactivity of creatine kinase or creatine kinase isoenzyme and (F) an effective amount of an antimicrobial to prevent microbial growth in the composition.;COPYRIGHT: (C)1994,JPO