Adenoviral vectors (VARIANTS), METHOD FOR THE PRODUCTION THEREOF, USE, replication-competent not contain adenovirus progeny METHOD FOR INCREASING THE BREEDING In complementing CELL LINE adenoviral vectors METHOD OF GENETIC MODIFICATION OF CELLS COMPOSITION host cell METHOD FOR TESTING Toxicity of adenoviral vectors, METHOD FOR TESTING OF EXPRESSION ALIEN GENE OR PASSENGER GENE OF THE Adenoviral vector

摘要

The present invention provides adenoviral vectors with multiple replication defects, having a spacer in at least one region of the replication-defective adenovirus, as well as complementing their cell lines. Also presented are means for constructing adenoviral vectors with multiple replication defects and methods for their use, for example, in gene therapy. The international application was published together with an international search report.