A method for increasing the frequency of implantation after implantation in vitro, a method for regulating fertility, a pharmaceutical composition, a method for increasing the frequency of implantation, and / or the frequency of perception.

摘要

The method provides an increase in the frequency of implantability and / or the incidence of pregnancy in women, includes the introduction of mammalian females, in the case of the desirability of pregnancy, an effective amount of: (a) a nitric oxide synthase substrate, a nitric oxide donor, or both, optionally in combination with (b) progestin and (c) optionally, optionally in combination with estrogen. The method also provides for the regulation of fertilization in female mammals and includes the introduction to women, in case of undesirability of pregnancy and at risk of pregnancy, an effective amount of a nitric oxide synthase inhibitor in combination with an antiprogestin. Pharmaceutical compositions are also proposed. The international application was published along with an international search report.