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COMPOSITIONS OF PROSTATE CANCER ANTIGENS AND METHODS OF ISOLATING AND/OR PRESERVING DENDRITIC CELLS FOR PROSTATE CANCER IMMUNOTHERAPY
COMPOSITIONS OF PROSTATE CANCER ANTIGENS AND METHODS OF ISOLATING AND/OR PRESERVING DENDRITIC CELLS FOR PROSTATE CANCER IMMUNOTHERAPY
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机译:前列腺癌抗原的组成以及用于前列腺癌免疫治疗的树突状细胞的分离和/或保存方法
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摘要
Methods and compositions for use of human dendritic cells to activate T cells for immunotherapeutic responses against primary and metastatic prostate cancer as disclosed. In one embodiment, human dendritic cells, after exposure to a prostate cancer antigen or specific antigenic peptide, are administered to a prostate cancer patient to activate the relevant T cell responses in vivo. In an alternate embodiment, human dendritic cells are exposed to a prostate cancer antigen or specific antigenic peptide in vitro and incubated or cultured with primed or unprimed T cells to activate the relevant T cell responses in vitro. The activated T cells are then administered to a prostate cancer patient. Methods and compositions for human dendritic cells with extended life span and cryopreserved dendritic cells are disclosed.
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