Piperazine derivatives which bind to 5-HT1A serotonergic receptors - used to treat neuromuscular dysfunctions of lower urinary tract

摘要

Piperazine derivatives of formula (I) and their salts and N-oxides and active metabolites are used for the treatment of neuromuscular dysfunction of the lower urinary tract. n = 1 or 2; Het = monocyclic heteroaryl; R = cycloalkyl or monocyclic heteroaryl; R3 = H or lower alkyl; Z = a bond, CH2, CH2CH2, CH2C(O), CH2CH(OH), O, OCH2,or CO; B' = optionally substituted aryl or heteroaryl; R1 = H, halo, alkoxy, NO2, NH2, acylamino or alkylsulphonylamino and R2 = halo, alkoxy, polyfluoroalkoxy, CN or carbamoyl. (I) are new provided that when Z = a bond, B' = a substituted phenyl of formula (a); and if R1 is not acylamino or alkylsulphonylamino, then R2 = polyfluoroalkoxy. 14 Compounds (I) are specifically claimed e.g: 1-[N-cyclohexylcarbonyl-N-(2-pyridyl)-2-aminoethyl]-4-(2-trifluoromethoxyphenyl)-piperazine.