PROCESS FOR THE SYNTHESIS OF SEMI-SYNTHETIC GLYCOSAMINOGLYCANS WITH HEPARIN OR HEPARAN STRUCTURE MODIFIED IN POSITION 2 OF THE .ALPHA.-L-IDURONIC-2-0-SULFATE ACID

摘要

A process for the synthesis of semi-synthetic glycosaminoglycans ofgeneral formula III(see fig. I)with heparin or heparan structure modified in position 2 of the.alpha.-L-iduronic-2-O-sulfate acid in which the sulfate group is, entirely or in part, substitutedwith a nucleophilic radical is described. Said process is carried out by treatingglycosaminoglycans with heparin or heparan structure by means of anucleophilic agent in alkaline medium.