Nonionic vitamin E derivatives, a process for producing the same, and an amphipathic macromolecule having an antioxidative activity formed therefrom

摘要

The present invention relates to a nonionic vitamin E derivative capable of forming an amphipathic polymer vesicle and a method for producing the same. More particularly, the present invention relates to a nonionic vitamin E or poly (vinyl alcohol) derivative represented by the following general formula (I) capable of forming an amphipathic polymer vesicle having an improved thermodynamic stability and excellent in vivo suitability and antioxidative physiological activity function, Ethoxylated vitamin E derivatives, processes for their preparation, and amphiphilic macromolecular vesicles obtained therefrom:;Wherein n is an integer from 0 to 30;;A is-CH₂-CH (CH₃)-or-CH = C (CH₃)-;;B is-CH RTI ID = 0.0 ₃ego;;m is an integer of 1 to 3;;R is an acrylate derivative or a methacrylate derivative represented by the following general formula (II).;In the above formula, R_OneIs H or CH₃to be.