IMMORTALIZED HEMATOPOIETIC CELL LINES, CELL SYSTEM THEREOF WITH STROMAL CELLS, IN VITRO, EX VIVO AND IN VIVO USES, AND IN VITRO GENERATION OF DENDRITIC CELLS AND MACROPHAGES

摘要

Extended life hematopoietic cell lines include stromal cell lines useful for the in vitro maintenance of undifferentiated pluripotent hematopoietic stem cells. Undifferentiated and differentiated immortalized stem cells are suitable for bone marrow transplantation, gene therapy and cell therapy applications, and as an in vitro model system for drug discovery and toxicological testing.