DNA FRAGMENT ENCODING NEISSERIA MEMINGITIDIS STRAIN B:4:P1:15 EXTERNAL MEMBRANE PROTEIN, EXTERNAL MEMBRANE PROTEIN OF NEISSERIA MENINGITIDIS, RECOMBINANT PLASMID DNA PM-6, STRAIN OF BACTERIUM ESCHERICHIA COLI HBM64, METHOD OF PRODUCING PROTEIN OF NEISSERIA MENINGITIDIS EXTERNAL MEMBRANE, VACCINE COMPOSITION

摘要

FIELD: molecular biology, genetic engineering, microbiology, vaccines. SUBSTANCE: invention relates to a method of isolation of a nucleotide sequence encoding protein (molecular mass is 64 000 Da) that is localized on external membrane of N. meningitidis cells and recombinant DNA obtained on said. Invention can be used for diagnosis methods and producing vaccines exhibiting the broad immunoprotection spectrum. EFFECT: identification of the nucleotide sequence encoding highly conservative protein, production of this protein, high purity of the protein. 11 cl, 6 dwg, 10 ex