New myxocheline derivatives useful e.g. for treating disorders associated with deficient metal ion metabolism, especially iron or aluminium metabolism, e.g. hemosiderosis, thalassemia or Alzheimer's disease

摘要

Myxocheline derivatives (I) and their salts are new. Myxocheline derivatives of formula (I) and their salts are new. R = COOH, COOR1, CH2-OH, CO-NR2R3, CN, CH2NR2R3, CO-Z, CH2-Z or a group of formula (i); R4 = COOH, COOR1, CH2-OH, CO-NR2R3, CN, CH2NR2R3 or a group of formula (ii); R1 = CxH2x+1, benzyl or phenyl; R2, R3 = H, CxH2x+1, benzyl or phenyl; Y = benzoyl, formyl, acetyl, trifluoroacetyl, glycosyl or silyl; Z = an organic group which is bound via O, N or S; n, x = 1-5; provided that: (1) R is not CH2NH2 or CN when n = 3 or 4, R4 = (ii) and Y = H; (2) R is not (i) with Y = H when n = 2-5, R4 = (ii) and Y = H; and (3) R is not CH2-OH or COOH when R4 = (ii) and Y = H, n = 4 and the absolute configuration at C asterisk is S. Independent claims are included for iron complexes of (I) and compounds (I) where Z is a dye (e.g. 2-oxoazetidin-1-sulfonic acid or 7-chloro-4-nitrobenz-2-oxa-1,3-diazole) or an antibiotic.