The use of the derivatives as inhibiting protein apolipoprotein B protein (or) of (apo B) secretion and production of isoquinoline-6-ylamide derivatives, birds and agent glycerides microsomal transfer protein - biphenyl-2-carboxylic acid - tetrahydro

摘要

The compounds of the summary formula 1, formula, X, or (57) CH _2, CO, CS, ₂ SO; (ie, covalent bond) Y is an aliphatic hydrocarbylene of up to 20 carbon atoms direct bond is a radical, the radical is mono substitution hydroxy, (C ₁ ~C ₁₀₎ alkoxy, (C ₁ ~C ₁₀₎ acyl, or (C ₁ ~C ₁₀₎ acyloxy, a (C ₆ ~C ₁₀₎ allyl radicals which may, NH, and one which is selected from O, X if is CH _2, then, is a direct bond Y; the Z, is selected from the following group: (1) H, halo , cyano, (2) hydroxy, (C ₁ ~C ₁₀₎ alkoxy, (C ₁ ~C ₁₀₎ alkylthio, (C ₁ ~C ₁₀₎ acyl, thiophenylcarbonyl, (C ₁ ~C ₁₀₎ alkoxycarbonyl, ( (C ₁ ~C ₁₀₎ alkylamino, di (C ₁ ~C ₁₀₎ alkylamino, (C ₆ ~C ₁₀₎ aryl (C ₁ ~C ₁₀₎ alkylamino, Y is not a NH or O, 3) ( condensation benz derivatives thereof 4) non-substituted vinyl, (C ₆ ~C ₁₀₎ aryl, and (C ₃ ~C ₈₎ cycloalkyl, (C ₇ ~C ₁₀₎ poly-cycloalkyl, (C ₄ ~C ₈₎ cyclo alkenyl, (C ₇ ~C ₁₀₎ poly cycloalkenyl, (5) (C ₆ ~C ₁₀₎ aryloxy, (C ₆ ~C ₁₀₎ arylthio, (C ₆ ~C ₁₀₎ aryl (C ₁ ~C ₁₀₎ The condensed multi-alkoxy, (C ₆ ~C ₁₀₎ aryl (C ₁ ~C ₁₀₎ alkylthio, (C ₃ ~C ₈₎ Cycloalkyloxy, (C ₄ ~C ₈₎ cycloalkenyloxy, (6) and one annular radical saturated heterocyclyl selected from the group consisting of the cyclic radicals, the radical is not the individual rings of the radicals of oxygen, nitrogen, and also contains a ring 4 heteroatoms total 1 is independently selected from sulfur Well, X if is CH _2, then even an aromatic ring or a saturated, or group H (4) and Z is one selected from (6), when Z contains one or more rings, Each separately, said ring from halo, hydroxy, cyano, nitro, oxo (O =), thioxo (S =), aminosulfonyl, phenyl, phenoxy, phenylthio, halo-phenylthio, benzyl, benzyloxy, (C ₁ ~C ₁₀₎ alkyl, (C ₁ ~C ₁₀₎ alkoxy, (C ₁ ~C ₁₀₎ alkoxycarbonyl, (C ₁ ~C ₁₀₎ alkylthio, (C ₁ ~C ₁₀₎ alkylamino, (C ₁ ~C ₁₀₎ alkyl aminocarbonyl, di (C ₁ ~C ₁₀₎ alkylamino, di (C ₁ ~C ₁₀₎ alkylaminocarbonyl, di (C ₁ ~C ₁₀₎ alkylamino (C ₁ ~C ₁₀₎ alkoxy, (C ₁ ~C ₃₎ perfluoroalkyl, (C ₁ ~C ₃₎ perfluoroalkoxy, (C ₁ ~C ₁₀₎ acyl, (C ₁ ~C ₁₀₎ acyloxy, (C ₁ ~C ₁₀₎ acyloxy (C ₁ ~C ₁₀₎ alkyl, and its salts 0 is selected from pyrrolidinyl individually to it, and may have a substituent 4, pharmaceutically acceptable. The present invention, useful atherosclerosis and to prevent and treat its clinical sequelae thereby triglyceride transfer protein of microsomes and also is an inhibitor B protein protein apolipoprotein (or) of (apo B) secretion on a compound. And compositions containing said compounds The present invention relates to a method of treating a compound of structure (or) atherosclerosis, obesity, and related diseases.