Aminoguanidinas and alcoxiguanidinas as protease inhibitors, alcoxiaminas for exclusive use in the process of obtaining such Compounds, Pharmaceutical composition,Use of such compounds and compositions for preparing Medicines, device used in the collection, circulation and storage of blood and Process for preparing such compounds.

摘要

1. Aminobenzene and methoxyguandinas have the first-order equation or acceptable solution, hydrate or salt on drugs; in the case that R1 is one of the substrates of dec3-8, cyclopentyl, acyl pyridine, tar, arilo, aralquilo or isobutylene, either of them can be replaced; Z is - n10so2-n10 -;-NR10C (RYRZ) -,-C (RYRZ) NR10- OSO2--SO2O- -OC (RYRZ) -NR10CO- o -CONR10-Ry and RZ are independent hydrogen, tar, cyclopentyl, arilo, aralquilo, hydroxy,R2, R3 and R4 are independent hydrogen, tar, cyclopentadiene, alquenilo, tar, arilo arlquilo, allotype, trifluoromethyl, red leaf, hydrogen, cyanogen, nitrate, carbohydrate, co2rx, ch2orx or orx, Or when they are on the adjacent carbon atom, R2 and R3 can also form a de-ch = CH-CH = ch-o - (CH2) Q, where q is entr e e 2 and 6, R4 is defined as before; Rx is independent hydrogen in each case,cycloalkyl alkyl wherein said alkyl or cycloalkyl groups may optionally have one or more unsaturations; Y is one of -O-, NR10-, -S-, CHR1 0- or a covalent bond; R10, in each case, is independently one of hydrogen, alkyl, aralkyl, aryl, hydroxyalkyl, aminoalkyl, monoalkylaminoalkyl (C2-10) dialkylaminoalkyl (C2-10) carboxyalkyl; X is oxygen or NR9; R9 is one of hydrogen, alkyl, cycloalkyl or aryl, wherein said alkyl, cycloalkyl or aryl may be optionally substituted with amino, monoalkylamino, dialkylamino, alkoxy, hydroxy, carboxy, alkoxycarbonyl, aryloxycarbonyl, aralkoxycarboyl nyl, aryl, heteroaryl, acylamino,Cyanogen or cyanogen trifluoride; n between 0 and 8; m in the middle